Search results for "Cytomegalovirus Positive"

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P043 HLA-DPB matching and donor cytomegalovirus positive (CMV+) status: An “unconventional alliance” associated with a decreased relapse incidence in…

2017

Aim While the role of HLA-DPB1 (DP) compatibility in uHSCT regarding graft versus host disease (GVHD)- and graft versus leukaemia (GVL)-effects has been extensively discussed, its interaction with donor CMV status (dCMV), remains elusive. The aim of this study was, to investigate the impact of dCMV status in DP matched (DPM) and mismatched (DPMM) uHSCT. Methods 1749 HSCT transplant (Tx) pairs were DP genotyped with an exon 2 amplicon based NGS approach in order to assess their DP matching status. CMV sero-status as well as clinical data were retrieved from the German Stem Cell Registry. Overall survival (OS), relapse incidence (RI) and chronic GvHD (cGvHD) were defined as endpoints, while s…

OncologyCMV statusmedicine.medical_specialtybusiness.industryIncidence (epidemiology)medicine.medical_treatmentImmunologyGeneral MedicineHuman leukocyte antigenHematopoietic stem cell transplantationmedicine.disease3. Good healthGraft-versus-host diseaseStatistical significanceInternal medicineImmunologyImmunology and AllergyMedicinebusinessCytomegalovirus PositiveCohort studyHuman Immunology

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